AI Article Synopsis
- The structure of this new compound and other related alkaloids were analyzed using advanced techniques like 1D & 2D NMR and HR-ESI-MS spectrometry.
- Additionally, the compounds (+)-sophoranol and lupanine were found to have biological activities, with sophoranol inhibiting nitric oxide production in macrophages and lupanine targeting human glioma stem cells.
Article Abstract
Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (), were isolated from the roots of Alt. The structure of compound was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)--dehydrosophoramine () and oxy--methylcytisine () were reported for the first time. In addition, (+)-sophoranol () exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC value of 22.14 μM, while lupanine () was found to inhibit the growth of human glioma stem cells GSC-3# at 20 μg/mL.
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| http://dx.doi.org/10.1080/14786419.2020.1817011 | DOI Listing |
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