AI Article Synopsis
- This study investigates how healthy adults' cerebrovascular reactivity (CVR) responds to changes in blood flow and oxygen using a new optical system that combines near-infrared spectroscopy and diffuse correlation spectroscopy.
- The research shows that scalp blood flow can interfere with the readings of oxygenation responses, especially for oxyhemoglobin, but using time-resolved NIRS can lessen this distortion.
- The findings highlight that this hybrid method is user-friendly, portable, and non-invasive, making it a valuable tool for exploring how factors like age and cerebrovascular diseases influence brain blood flow and oxygenation dynamics.
Article Abstract
This study presents the characterization of dynamic cerebrovascular reactivity (CVR) in healthy adults by a hybrid optical system combining time-resolved (TR) near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). Blood flow and oxygenation (oxy- and deoxy-hemoglobin) responses to a step hypercapnic challenge were recorded to characterize dynamic and static components of CVR. Data were acquired at short and long source-detector separations ( ) to assess the impact of scalp hemodynamics, and moment analysis applied to the TR-NIRS to further enhance the sensitivity to the brain. Comparing blood flow and oxygenation responses acquired at short and long demonstrated that scalp contamination distorted the CVR time courses, particularly for oxyhemoglobin. This effect was significantly diminished by the greater depth sensitivity of TR NIRS and less evident in the DCS data due to the higher blood flow in the brain compared to the scalp. The reactivity speed was similar for blood flow and oxygenation in the healthy brain. Given the ease-of-use, portability, and non-invasiveness of this hybrid approach, it is well suited to investigate if the temporal relationship between CBF and oxygenation is altered by factors such as age and cerebrovascular disease.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449704 | PMC |
| http://dx.doi.org/10.1364/BOE.392113 | DOI Listing |
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