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We have measured the ocular transverse chromatic aberration (TCA) in 11 subjects using 2D-two-color Vernier alignment, for two pupil diameters, in a polychromatic adaptive optics (AO) system. TCA measurements were performed for two pupil diameters: for a small pupil (2-mm), referred to as 'optical TCA' (oTCA), and for a large pupil (6-mm), referred to 'perceived TCA' (pTCA). Also, the TCA was measured through both natural aberrations (HOAs) and AO-corrected aberrations. Computer simulations of pTCA incorporated longitudinal chromatic aberration (LCA), the patient's HOAs measured with Hartmann-Shack, and the Stiles-Crawford effect (SCE), measured objectively by laser ray tracing. The oTCA and the simulated pTCA (no aberrations) were shifted nasally 1.20 arcmin and 1.40 arcmin respectively. The experimental pTCA (-0.27 arcmin horizontally and -0.62 vertically) was well predicted (81%) by simulations when both the individual HOAs and SCE were considered. Both HOAs and SCE interact with oTCA, reducing it in magnitude and changing its orientation. The results indicate that estimations of polychromatic image quality should incorporate patient's specific data of HOAs, LCA, TCA & SCE.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449748 | PMC |
http://dx.doi.org/10.1364/BOE.396469 | DOI Listing |
Front Neurosci
December 2024
Intramural Research Program, National Institute on Drug Abuse National Institutes of Health, Baltimore, MD, United States.
Miniature fluorescence microscopes (miniscopes) are one of the most powerful and versatile tools for recording large scale neural activity in freely moving rodents with single cell resolution. Recent advances in the design of genetically encoded calcium indicators (GECIs) allow to target distinct neuronal populations with non-overlapping emission spectral profiles. However, conventional miniscopes are limited to a single excitation, single focal plane imaging, which does not allow to compensate for chromatic aberration and image from two spectrally distinct calcium indicators.
View Article and Find Full Text PDFBiomed Opt Express
December 2024
Departamento de Óptica y Optometría y Ciencias de la Visión, Universitat de València, Burjassot, Spain.
In this work, we present two new multifocal intraocular lens (MIOL) designs, both based on the silver mean kinoform diffractive lens. We demonstrate that a single aperiodic diffractive profile can be used to create two different MIOLs: one with a kinoform structure and the other with a stepwise profile. Quantitative assessment of the designs was carried out using the through focus modulation transfer function and the area under the modulation transfer function for the prediction of their visual performance.
View Article and Find Full Text PDFBiomed Opt Express
December 2024
Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya - BarcelonaTech, Violinista Vellsolà 37, 08222 Terrassa, Spain.
This study investigates whether a diffractive presbyopia-correcting multifocal intraocular lens disrupts the favorable interaction between chromatic and monochromatic aberrations in the eye. This is analyzed not only for distant objects but also for closer viewing distances, where the lens utilizes different diffraction orders depending on its design. We consider diffractive designs based on the zero-diffraction order for far vision and the first diffraction order for near vision (i.
View Article and Find Full Text PDFAsia Pac J Ophthalmol (Phila)
December 2024
The Primasia International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China. Electronic address:
Myopia has ever-rising prevalence in the past few decades globally. Its pathogenesis is still not adequately elucidated especially at the signal transduction level. For the environmental risk factors, there is a large body of fragmented knowledge about the visual inputs for accommodation, myopiagenesis and emmetropization, with the latter two being essentially local processes.
View Article and Find Full Text PDFCoherent diffraction imaging (CDI) is a lens-free imaging paradigm that avoids the diffraction limit caused by lens chromatic aberration. However, due to the ill-posed problem of phase retrieval, experiments often require the collection of multiple diffraction patterns for image reconstruction, which limits its application in dynamic imaging scenarios. In this Letter, we propose a physics-embedded untrained neural network for snapshot coherent diffraction imaging.
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