Brodalumab in the treatment of recalcitrant acrodermatitis continua of Hallopeau.

Dermatol Ther

Department of Experimental, Diagnostic, and Specialty Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.

Published: November 2020

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.14301DOI Listing

Publication Analysis

Top Keywords

brodalumab treatment
4
treatment recalcitrant
4
recalcitrant acrodermatitis
4
acrodermatitis continua
4
continua hallopeau
4
brodalumab
1
recalcitrant
1
acrodermatitis
1
continua
1
hallopeau
1

Similar Publications

Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. Although it has demonstrated favorable efficacy and safety in clinical trials, the strict inclusion and exclusion criteria may not fully reflect its safety profile in real-world settings. As its use becomes more widespread in clinical practice, understanding its safety in real-world applications is crucial.

View Article and Find Full Text PDF

Obesity is a metabolic disease that is marked by excessive fat accumulation and is objectively defined as a body mass index (BMI) ≥30 kg/m2. Obesity is associated with several other comorbidities, including psoriasis, which is a chronic autoimmune skin disease. Adipocytes produce pro-inflammatory signaling molecules, namely adipokines and classic cytokines, that drive increased inflammation axnd may contribute to the pro-inflammatory pathways driving psoriasis disease pathogenesis.

View Article and Find Full Text PDF
Article Synopsis
  • * The study evaluates the effectiveness and safety of various treatments for non-radiographic axial spondyloarthritis (nr-axSpA), including tumour necrosis factor inhibitors (TNFi), interleukin-17 inhibitors (IL-17i), and Janus kinase inhibitors (JAKi).
  • * A systematic review covered 10 randomized controlled trials with 2,418 participants, utilizing multiple databases and statistical software to analyze data on treatment efficacy and adverse events.
  • * Results showed that certolizumab pegol was the most effective, followed by other treatments like golimumab and bimekizumab, with most therapies significantly improving symptoms compared to placebo; however, safety profiles varied among treatments.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!