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Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice.
Nat Commun
January 2025
Department of Integrative Biology & Physiology, University of California, Los Angeles, CA, USA.
The gut microbiome modulates the anti-seizure effects of the ketogenic diet, but how specific dietary formulations differentially modify the gut microbiome in ways that impact seizure outcome is poorly understood. We find that medical ketogenic infant formulas vary in macronutrient ratio, fat source, and fiber content and differentially promote resistance to 6-Hz seizures in mice. Dietary fiber, rather than fat ratio or source, drives substantial metagenomic shifts in a model human infant microbial community.
View Article and Find Full Text PDFRELMβ sets the threshold for microbiome-dependent oral tolerance.
Nature
January 2025
Division of Immunology, Boston Children's Hospital, Boston, MA, USA.
Tolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis. However, the mechanisms resulting in both the maintenance and failure of tolerance to food antigens are poorly understood. Here we demonstrate that the goblet-cell-derived resistin-like molecule β (RELMβ) is a critical regulator of oral tolerance.
View Article and Find Full Text PDFEffect of different 3D-printing systems on the flexural strength of provisional fixed dental prostheses: a systematic review and network meta-analysis of in vitro studies.
BMC Oral Health
January 2025
Department of Restorative Dentistry, Recep Tayyip Erdoğan University, Rize, Turkey.
Objectives: The aim of this systematic review and network meta-analysis was to compare the flexural strength of provisional fixed dental prostheses (PFDPs) fabricated using different 3D printing technologies, including digital light processing (DLP), stereolithography (SLA), liquid crystal display (LCD), selective laser sintering (SLS), Digital Light Synthesis (DLS), and fused deposition modeling (FDM).
Materials And Methods: A comprehensive literature search was conducted in databases including PubMed, Web of Science, Scopus, and Open Grey up to September 2024. Studies evaluating the flexural strength of PFDPs fabricated by 3D printing systems were included.
Trueness and Internal Fit of 3D Printed Provisional Veneers: An In Vitro Comparative Study.
Bioengineering (Basel)
November 2024
Department of Prosthodontics, University of Medicine and Pharmacy "Victor Babes", B-dul Revolutiei 1989, No. 9, 300580 Timisoara, Romania.
Dentistry is steadily evolving along the digital pathway at a constant and sure pace. Intraoral scanners (IOSs) started to enhance the precision and trueness of the restorations, making prosthodontics treatment more predictable. The objective of this study was to compare the trueness and internal fit of the printed provisional veneers for 60 preparations with three different types of finish lines.
View Article and Find Full Text PDFOver-provisionals - Simplified chairside preoperative evaluation of esthetic and functional changes during full mouth rehabilitation.
J Indian Prosthodont Soc
January 2025
Department of Prosthodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Prosthetic rehabilitation in multifaceted dental abnormality needs sequential planning to ensure adaptation of oral and associated musculature. Reduction of tooth structure before adaptation of oral and associated components may complicate the treatment modality if compliance of the musculature is poor. Hence, the fabrication of over-provisional in esthetic rehabilitation enables to assess of the success of the treatment plan preoperatively before invasive trials.
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