Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yjmcc.2020.09.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dissecting the multifaceted roles of autophagy in cancer initiation, growth, and metastasis: from molecular mechanisms to therapeutic applications.
Med Oncol
June 2024
Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh.
Autophagy is a cytoplasmic defense mechanism that cells use to break and reprocess their intracellular components. This utilization of autophagy is regarded as a savior in nutrient-deficient and other stressful conditions. Hence, autophagy keeps contact with and responds to miscellaneous cellular tensions and diverse pathways of signal transductions, such as growth signaling and cellular death.
View Article and Find Full Text PDFAutophagy: A savior in cigarette smoke-induced cardiac injury.
J Mol Cell Cardiol
November 2020
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United States. Electronic address:
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
Toxicol Mech Methods
January 2017
a Department of Life Sciences , National Institute of Technology, Rourkela , India.
Polycyclic aromatic hydrocarbons (PAHs) comprise the major class of cancer-causing chemicals and are ranked ninth among the chemical compounds threatening to humans. Moreover, interest in PAHs has been mainly due to their genotoxic, teratogenic, mutagenic and carcinogenic property. Polymorphism in cytochrome P450 (CYP450) and aryl hydrocarbon receptor (AhR) has the capacity to convert procarcinogens into carcinogens, which is an imperative factor contributing to individual susceptibility to cancer development.
View Article and Find Full Text PDFAutophagy in ALDH2-elicited cardioprotection against ischemic heart disease: slayer or savior?
Autophagy
November 2010
Department of Cardiology; Xijing Hospital; Fourth Military Medical University; Xi'an, China; Center for Cardiovascular Research and Alternative Medicine; University of Wyoming; Laramie, WY USA.
The mitochondrial isoform of aldehyde dehydrogenase (ALDH2) plays a key role in the metabolism of acetaldehyde and other toxic aldehydes. A recent seminal finding has indicated a potential role of ALDH2 activation in the cardioprotection against ischemic injury. Data from our group unveiled a myocardial protective effect of ALDH2 against ischemia/reperfusion (I/R) injury possibly through detoxification of toxic aldehydes: and a differential regulation of autophagy mediated by AMPK-mTOR and Akt-mTOR signaling cascades during ischemia and reperfusion, respectively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!