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10-Year Risk of Gallstones in Congenital Red Blood Cell Disorder Patients: A Nationwide Cohort Study.
Am J Hematol
February 2025
Department of Hematology, Odense University Hospital, Odense, Denmark.
Chronic hemolysis potentially elevates the risk of gallstones in several types of congenital red blood cell (RBC) disorders. However, the magnitude of the risk is unknown. We investigate the risk of gallstone disease in congenital RBC disorder patients, compared with general population comparators.
View Article and Find Full Text PDFAcute Pancreatitis in Individuals with Sickle Cell Disease: A Systematic Review.
J Clin Med
August 2024
Stead Family Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of Iowa, Iowa City, IA 52242, USA.
Article Synopsis
- The systematic review aimed to compare the prevalence and severity of AP in SCD patients vs. the general population, analyzing multiple studies, including case reports and cohort studies.
- Out of 296 studies screened, 33 were relevant, revealing that AP prevalence in SCD was estimated at 2% to 7%; however, existing data on AP in SCD patients is limited, and future studies are needed for more insights.
Splenectomy in Thalassemia: The Role of Surgery as an Adjunct to Medical Management.
Cureus
June 2024
Department of General Surgery, Tata Main Hospital, Jamshedpur, IND.
Introduction Beta thalassemia is a hemoglobinopathy characterized by defective production of the beta chain of hemoglobin, leading to irreversible destruction of RBCs, splenomegaly, pancytopenia, and a requirement for multiple transfusions. This condition necessitates iron chelation therapy, and splenectomy is often performed to manage hypersplenism. Methods This report includes a series of seven diagnosed cases of beta thalassemia with hypersplenism, all of whom underwent open splenectomy.
View Article and Find Full Text PDFKey Clinical Message: When a person has both HS and beta-thalassemia, their clinical symptoms tend to be less severe. This is because these two conditions have contrasting features. If the clinical symptoms and laboratory results cannot be solely attributed to hemolytic anemia, it is important to consider the possibility of another form of hemolytic anemia coexisting.
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