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Coronavirus disease 2019 (COVID-19) still causes death in elderly and immunocompromised individuals, for whom the sustainability of the vaccine response may be limited. Antiviral treatments, such as remdesivir or molnupiravir, have demonstrated limited clinical efficacy. Nirmatrelvir, an acute respiratory syndrome coronavirus 2 (SARS-CoV-2) major protease inhibitor, is clinically effective but has been associated with viral rebound and antiviral resistance.
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School of Environmental and Natural Sciences, Bangor University, Bangor, Gwynedd, LL57 2UW, UK.
Article Synopsis
- CI-qPCR assays provide a viable alternative to traditional cell culture methods for assessing virus viability in wastewater, specifically focusing on human pathogens.
- The study evaluated three CI-qPCR methods (Crosslinker, TruTiter, and PMAxx) on various viruses like HAdV and SARS-CoV-2, revealing differences in sensitivity and effectiveness between them.
- Findings suggest that while PMAxx struggled with detecting certain heat-inactivated viruses, both PMAxx and TruTiter successfully identified intact viruses in wastewater, showing promise for improving public health monitoring and response to emerging viral threats.
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