Arch Toxicol
Leibniz Research Center for Working Environment and Human Factors, Ardeystr. 67, 44139, Dortmund, Germany.
Published: October 2020
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http://dx.doi.org/10.1007/s00204-020-02890-4 | DOI Listing |
Eur J Neurosci
March 2025
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, and metabolism. In Drosophila, an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters.
View Article and Find Full Text PDFBackground: The biological reproductive process requires the precise coordination of annual and daily signals to adapt to environmental shifts. Humans and animals have developed shared neuroendocrine systems that have adapted to process daily and seasonal light signals within the hypothalamic-pituitary -gonadal axis. However, the stability of circadian and seasonal biological processes is at risk due to industrialization and contemporary round-the-clock lifestyles.
View Article and Find Full Text PDFCancers (Basel)
February 2025
Department of Dermatology, Oregon Health & Science University, Portland, OR 97239, USA.
In the era of precision medicine, mounting evidence suggests that the time of therapy administration, or chronotherapy, has a great impact on treatment outcomes. Chronotherapy involves planning treatment timing by considering circadian rhythms, which are 24 h oscillations in behavior and physiology driven by synchronized molecular clocks throughout the body. The value of chronotherapy in cancer treatment is currently under investigation, notably in the effects of treatment timing on efficacy and side effects.
View Article and Find Full Text PDFSci Rep
March 2025
School of Psychology, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigated a conditional liver-specific knockout mouse model (Npas2-/- or cKO) to explore its function in activity, circadian rhythms and cognition (novel object recognition-NOR). Circadian rhythms showed no genotype differences.
View Article and Find Full Text PDFInt J Dermatol
March 2025
Centre Médical Saint Jean, Arras, France.
The concept of aging has evolved from being primarily attributed to genetic factors to recognizing the critical role of epigenetic mechanisms. Recent advancements, such as epigenetic clocks, have provided tools to assess biological age and offer insights into aging processes at the molecular level. In aesthetic dermatology, understanding these processes allows for more personalized, effective interventions targeting the root causes of skin aging.
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