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| http://dx.doi.org/10.1038/s41386-020-00850-1 | DOI Listing |
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Patient-reported visual function outcomes agree with visual acuity and ophthalmologist-graded scoring of visual function among patients with long-chain 3-hydroxyacylcoA dehydrogenase deficiency (LCHADD).
Mol Genet Metab Rep
December 2024
Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Patients with LCHADD develop progressive chorioretinopathy with vision loss over time. To date, no data on the impact of vision loss on patient vision-specific activities of daily living or quality of life have been reported. We used validated ophthalmic patient-reported outcome measures (PROMs) to compare the impact of patient-perceived visual function to visual acuity and an ophthalmologist-graded stage of LCHADD chorioretinopathy.
View Article and Find Full Text PDFBrain-like Flexible Visual Inference by Harnessing Feedback-Feedforward Alignment.
Adv Neural Inf Process Syst
December 2023
Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University New York, NY.
Article Synopsis
- * It introduces a new learning algorithm called Feedback-Feedforward Alignment (FFA), which optimizes the interaction between feedforward and feedback pathways for better visual inference tasks like classification and reconstruction.
- * The study highlights FFA's effectiveness in achieving these tasks and its bio-plausibility compared to traditional methods, suggesting it may offer insights into how visual processing functions in the brain.
Machine vision based frailty assessment for genetically diverse mice.
bioRxiv
October 2024
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609.
Frailty indexes (FIs) capture health status in humans and model organisms. To accelerate our understanding of biological aging and carry out scalable interventional studies, high-throughput approaches are necessary. We previously introduced a machine vision-based visual frailty index (vFI) that uses mouse behavior in the open field to assess frailty using C57BL/6J (B6J) data.
View Article and Find Full Text PDFAutomated multimodal imaging of Caenorhabditis elegans behavior in multi-well plates.
Genetics
October 2024
Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH 43210, USA.
Article Synopsis
- Researchers created a new automated system to study the behavior of C. elegans, a type of nematode, which allows for the analysis of 96 worms simultaneously using high-resolution imaging.
- The system tracks and quantifies various behaviors, such as locomotion and egg-laying, by applying computer vision techniques.
- Findings revealed that serotonin affects C. elegans behavior, showing that reduced movement occurs before egg-laying and that specific serotonin receptors play important roles in this process, making the system valuable for further behavioral research.
Probabilistic modeling reveals coordinated social interaction states and their multisensory bases.
bioRxiv
August 2024
Department of Anatomy & Physiology, University of Melbourne, Parkville, VIC, Australia.
Social behavior across animal species ranges from simple pairwise interactions to thousands of individuals coordinating goal-directed movements. Regardless of the scale, these interactions are governed by the interplay between multimodal sensory information and the internal state of each animal. Here, we investigate how animals use multiple sensory modalities to guide social behavior in the highly social zebrafish () and uncover the complex features of pairwise interactions early in development.
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