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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489900 | PMC |
| http://dx.doi.org/10.1074/jbc.RX120.015586 | DOI Listing |
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Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, 25250 Vestec, Czechia. Electronic address:
Microtubules (MTs) are dynamically unstable polar biopolymers switching between periods of polymerization and depolymerization, with the switch from the polymerization to the depolymerization phase termed catastrophe and the reverse transition termed rescue. In presence of MT-crosslinking proteins, MTs form parallel or anti-parallel overlaps and self-assemble reversibly into complex networks, such as the mitotic spindle. Differential regulation of MT dynamics in parallel and anti-parallel overlaps is critical for the self-assembly of these networks.
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