p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article and the accompanying poster, we focus on the signaling cascades regulating TAp63 and ΔNp63 isoforms and those that are regulated by TAp63 and ΔNp63, as well the role of p63 in disease.
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| http://dx.doi.org/10.1242/jcs.228015 | DOI Listing |
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Article Synopsis
- TGFβ plays a significant role in inflammation, wound healing, and cancer, acting as a tumor suppressor in squamous cell carcinoma (SCC), which is linked to high ΔNp63 levels.
- Research shows that TGFβ selectively increases ΔNp63 protein in healthy cells via canonical signaling, but the relationship between mRNA levels and protein is complicated, showing initial increases followed by later declines.
- The interactions between TGFβ and p63 may affect epithelial-to-mesenchymal transition and influence tumor behavior and treatment responses in SCC.
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