AI Article Synopsis
- This study explored the effectiveness of extracorporeal shock wave therapy (ESWT) in improving hypertrophic scar regeneration after skin grafting through a double-blind, randomized trial with 48 participants.
- Results indicated that the ESWT group showed significant improvements in scar thickness and erythema compared to the control group, as well as increased sebum levels, while no significant differences were found in melanin levels or skin elasticity.
- The findings suggest ESWT has beneficial effects on the characteristics of burn-related scars, marking it as the first study to utilize objective measurement tools in this context.
Article Abstract
Purpose: This study aimed to investigate the regeneration effect of extracorporeal shock wave therapy (ESWT) on hypertrophic scar regeneration using objective measurements.
Methods: This was a double-blinded, randomized, controlled trial of 48 participants who had undergone autologous split-thickness skin grafting (STSG) with same artificial dermis. The ESWT group (n=25) received shock waves with low-energy flux density (0.05-0.30mJ/mm). The interval between treatments is a 1-week. The ESWT group also received recommended treatment. The control group (n=23) only received standard treatment. We measured skin characteristics before treatment and after 6 weeks for both groups.
Results: No significant intergroup difference was noted at the initial evaluations (p>0.05). The pre- to post-treatment change in the scar thickness (p=0.03) and erythema (p=0.03), greater reduction was found in the ESWT group than control group. The pre- to post-treatment change in the sebum level (p=0.02), more increase was found in the ESWT group. We found no significant differences in the change measurements between the two groups for melanin levels (p=0.62) and transepidermal water loss (TEWL) (p=0.94). The changes (skin distensibility, biological skin elasticity, gross skin elasticity, and skin viscoelasticity) measured with the Cutometer showed no significant differences between the two groups (p=0.87, p=0.32, p=0.37, and p=0.29, respectively).
Conclusion: This is the first report of ESWT on hypertrophic scar after burn using objective tools (melanin, erythema, sebum, TEWL, elasticity and thickness). ESWT has objective beneficial effects on burn-associated scar characteristics.
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| http://dx.doi.org/10.1016/j.burns.2020.08.009 | DOI Listing |
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