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Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis.
Front Cell Infect Microbiol
January 2025
College of Environmental and Life Sciences, Murdoch University, Perth, WA, Australia.
Background: Ammonia (NH) and hydrogen sulfide (HS) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.
Methods: We systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH and/or HS, male infertility, and gut microbiota. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.
Ecogenomic insights into the resilience of keystone Blastococcus Species in extreme environments: a comprehensive analysis.
BMC Genomics
January 2025
Department of Biological and Chemical Engineering, USCR Molecular Bacteriology and Genomics, University of Carthage, National Institute of Applied Sciences and Technology, Tunis, 2080, Tunisia.
Background: The stone-dwelling genus Blastococcus plays a key role in ecosystems facing extreme conditions such as drought, salinity, alkalinity, and heavy metal contamination. Despite its ecological significance, little is known about the genomic factors underpinning its adaptability and resilience in such harsh environments. This study investigates the genomic basis of Blastococcus's adaptability within its specific microniches, offering insights into its potential for biotechnological applications.
View Article and Find Full Text PDFThe interplay between mitochondrial DNA genotypes, female infertility, ovarian response, and mutagenesis in oocytes.
Hum Reprod Open
December 2024
Vrije Universiteit Brussel (VUB), Brussels Health Campus/Faculty of Medicine and Pharmacy, Research Group Genetics, Reproduction and Development , Laarbeeklaan 103, 1090 Brussels, Belgium.
Study Question: Is there an association between different mitochondrial DNA (mtDNA) genotypes and female infertility or ovarian response, and is the appearance of variants in the oocytes favored by medically assisted reproduction (MAR) techniques?
Summary Answer: Ovarian response was negatively associated with global non-synonymous protein-coding homoplasmic variants but positively associated with haplogroup K; the number of oocytes retrieved in a cycle correlates with the number of heteroplasmic variants in the oocytes, principally with variants located in the hypervariable (HV) region and rRNA loci, as well as non-synonymous protein-coding variants.
What Is Known Already: Several genes have been shown to be positively associated with infertility, and there is growing concern that MAR may facilitate the transmission of these harmful variants to offspring, thereby passing on infertility. The potential role of mtDNA variants in these two perspectives remains poorly understood.
Catalyst for change: Psilocybin's antidepressant mechanisms-A systematic review.
J Psychopharmacol
January 2025
Division of Clinical Psychological Intervention, Freie Universität Berlin, Berlin, Germany.
Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies have investigated distinct mechanisms and proposed theoretical opinions, a comprehensive understanding of psilocybin's neurobiological and psychological antidepressant mechanisms is lacking.
Aims: Systematically review potential antidepressant neurobiological and psychological mechanisms of psilocybin.
The impact of mercury exposure on male reproduction: Mechanistic insights.
J Trace Elem Med Biol
January 2025
Indiana University, Department of Biochemistry and Molecular Biology, Indianapolis, USA. Electronic address:
Mercury is a pervasive environmental toxin with significant negative effects on human health. In occupational settings, incidents such as the Minamata and Niigata disease in Japan and the large-scale methylmercury poisoning in Iraq have highlighted the severe health impacts of mercury exposure. It is widely accepted that all forms of mercury including methylmercury and mercuric chloride have the potential to induce toxic effects in mammals, and there is increasing concern about the impact of environmentally relevant levels of mercury on reproductive functions.
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