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The association between mortality due to COVID-19 and coagulative parameters: a systematic review and meta-analysis study.
BMC Infect Dis
December 2024
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Aims And Objectives: This systematic review and meta-analysis study evaluated the association between mortality due to COVID-19 and coagulative factors.
Methods: A systematic search was conducted on electronic databases including PubMed, Scopus, and the Web of Science from the beginning of the pandemic until October 2024 to identify relevant studies on COVID-19 patients and their laboratory findings related to coagulation markers and mortality outcome. Eligibility criteria were defined based on the PICO framework, and data extraction was performed by two authors independently using a standardized sheet.
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced pneumonitis results in a prothrombotic and hypercoagulable state. Prognostic indicators are crucial for identifying patients at risk of complications. D-dimer, a degradation product of cross-linked fibrin, is a specific marker for thrombosis.
View Article and Find Full Text PDFA multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV.
Clin Epigenetics
November 2024
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE #3049, Atlanta, GA, 30322, USA.
Article Synopsis
- * Researchers conducted single-trait epigenome-wide association studies (EWAS) focusing on three inflammatory markers in a study of 920 male PWH, predominantly Black and averaging 51 years old.
- * By utilizing multi-trait EWAS methods, they discovered numerous DNAm sites associated with inflammation, many of which were not identified in single-trait analyses, highlighting crucial inflammation-related genes and pathways that could help address chronic inflammation in PWH.
[Direct Oral Anticoagulants in elderly with multimorbidity: what precautions?].
Rev Med Suisse
October 2024
Centre universitaire de traitement et de réadaptation gériatrique, Service de gériatrie, Département de médecine, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Article Synopsis
- - Elderly patients with multiple health issues are more likely to experience problems from direct oral anticoagulants (DOAC), especially if they have kidney issues, are very old or underweight, or take many medications.
- - A medication review and assessment of DOAC use can help identify those at risk for bleeding, utilizing the expertise of coagulation specialists and specific blood tests to measure drug levels and clotting indicators.
- - If DOAC-related issues are found, experts can recommend tailored solutions, like reducing the dosage or switching to a different anticoagulant medication.
Exploring the Prognostic Role of D-dimer Levels in Pancreatic Cancer: A Comprehensive Review of Clinicopathological Associations.
Cureus
September 2024
General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Pancreatic cancer is known for its dismal prognosis and high mortality rate, primarily due to late-stage diagnosis and aggressive disease progression. Finding reliable prognostic biomarkers is crucial in improving patient outcomes and guiding treatment strategies. D-dimer, a fibrin degradation product, has emerged as a potential biomarker of interest in various cancers due to its association with coagulation abnormalities.
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