AI Article Synopsis
- Gastrointestinal autonomic neuropathy is a serious but often overlooked condition related to diabetic autonomic neuropathy that greatly affects patients' quality of life.
- There is no direct test for assessing nerve damage in the gastrointestinal system; instead, cardiovascular autonomic reflex tests are inconsistently used, leading to gaps in diagnosis.
- Common issues like diabetic gastroparesis (delayed gastric emptying) exemplify this condition, which can impact any part of the digestive tract and is challenging to manage effectively with current options.
Article Abstract
Gastrointestinal autonomic neuropathy represents an important and diverse, but poorly appreciated, manifestation of diabetic autonomic neuropathy that impacts negatively on quality of life. There is no test to assess gastrointestinal autonomic nerve damage directly in humans; cardiovascular autonomic reflex tests are often used as a surrogate, but are suboptimal. Gastrointestinal symptoms are common in diabetes, but usually correlate only weakly with disordered motility. Diabetic gastroparesis, or abnormally delayed gastric emptying, occurs frequently and is the best characterized manifestation of gastrointestinal autonomic neuropathy. There is a bi-directional relationship between postprandial glycaemia and the rate of gastric emptying. However, autonomic neuropathy can affect the function of any gut segment from the esophagus to the anus. Current management options for gastrointestinal autonomic neuropathy are, for the main part, empirical and sub-optimal.
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| http://dx.doi.org/10.1016/j.autneu.2020.102718 | DOI Listing |
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