AI Article Synopsis
- Muse cells are non-tumorigenic, pluripotent-like cells in bone marrow that help repair tissues by replacing damaged cells and are investigated for their potential in treating post-hepatectomy liver failure (PHLF).
- In a study with swine, Muse cells were administered through the portal vein following a 70% liver removal, showing characteristics similar to human Muse cells.
- Results indicated that these Muse cells effectively migrated to the liver, improved liver function markers, and differentiated into liver cells, suggesting their potential for aiding recovery in PHLF cases.
Article Abstract
Introduction: Multilineage-differentiating stress-enduring (Muse) cells are non-tumorigenic endogenous pluripotent-like cells residing in the bone marrow that exert a tissue reparative effect by replacing damaged/apoptotic cells through spontaneous differentiation into tissue-constituent cells. Post-hepatectomy liver failure (PHLF) is a potentially fatal complication. The main purpose of this study was to evaluate the safety and efficiency of allogeneic Muse cell administration via the portal vein in a swine model of PHLF.
Methods: Swine Muse cells, collected from swine bone marrow-mesenchymal stem cells (MSCs) as SSEA-3(+) cells, were examined for their characteristics. Then, 1 × 10 allogeneic-Muse cells and allogeneic-MSCs and vehicle were injected via the portal vein in a 70% hepatectomy swine model.
Results: Swine Muse cells exhibited characteristics comparable to previously reported human Muse cells. Compared to the MSC and vehicle groups, the Muse group showed specific homing of the administered cells into the liver, resulting in improvements in the control of hyperbilirubinemia (P = 0.04), prothrombin international normalized ratio (P = 0.05), and suppression of focal necrosis (P = 0.04). Integrated Muse cells differentiated spontaneously into hepatocyte marker-positive cells.
Conclusions: Allogeneic Muse cell administration may provide a reparative effect and functional recovery in a 70% hepatectomy swine model and thus may contribute to the treatment of PHLF.
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| http://dx.doi.org/10.1007/s00595-020-02117-0 | DOI Listing |
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