The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586391 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.0c02725 | DOI Listing |
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