Differential blood count is an excellent complementary test to complete blood count, which allows analysis of the white cell differentiation and their morphologic particularity. As the tendency currently leads to targeted laboratory analysis, differential blood count provides a diagnostic and prognostic value in many clinical situations, notably in patients with an infection. Based on clinical cases, this article reviews the different white blood cell lines to provide key points for interpretation of qualitative and quantitative anomalies encountered in the daily hospital practice.

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