Rhizarthrosis is a progressive and disabling pathology affecting the carpometacarpal joint. It's very common in elderly patients and typically affects postmenopausal women. The diagnosis of rhizarthrosis is mainly made by using different physical examination tests and by evaluating the type of pain and it's then confirmed by imaging. Over the last few years increasing attention has been devoted to the assessment of new treatment techniques for rhizarthrosis. In this context intra-articular injection of autologous fat grafting for cartilage regeneration has demonstrated promising results in experimental settings as an alternative to open surgery procedures. The aim of this study was therefore to sum up the evidences available so far on autologous fat grafting as an emerging treatment for patients affected by carpometacarpal rizarthrosis. An electronic literature research was carried out on Pubmed, Google Scholars and Cochrane Library using "fat grafting", "fat graft", "adipose", "fat transfer" and "lipoaspirate" as search terms. Authors believe autologous fat grafting is an interesting technique, that hand surgeon should keep in mind especially in early stages of rhizarthrosis were pain has not been solved with non-surgical treatment.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459373 | PMC |
http://dx.doi.org/10.4081/or.2020.8666 | DOI Listing |
Aesthet Surg J
January 2025
Plastic surgeon in private practice, Guadalajara, México.
Background: Autologous fat grafting in the buttocks has gained great popularity However, one of the main risks is infiltration of fat into the systemic venous system, leading to potential complications such as macroscopic fatty embolism (MAFE), which can be fatal.
Objectives: This study evaluated the safety and efficacy of the LiRi (Linear Retrograde infiltration) for autologous fat grafting in the buttocks, and its evolution over a six-month follow-up period.
Methods: The procedure was performed in 114 patients.
Aesthetic Plast Surg
January 2025
Department of Body Contouring and Fat grafting Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No 33 Badachu Road, Shijingshan District, 100144, Beijing, People's Republic of China.
Background: Superficial autologous fat grafting is widely used for facial rejuvenation and regenerative treatments, yet its retention rate remains unpredictable. Enhancing the concentration of adipose-derived stem cells (ASCs) has been shown to improve graft retention. Mechanical fat processing techniques can reduce fat granules size for superficial injection as well as elevate the concentration of ASCs.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing 100144, People's Republic of China. Electronic address:
Autologous fat grafting is a widely used technique in plastic and reconstructive surgery, but its efficacy is often limited by the poor survival rate of transplanted adipose tissue. This study aims to enhance the survival of fat grafts by investigating the role of thymosin beta-4 (Tβ4) in facilitating mitochondrial transfer from adipose-derived stem cells (ADSCs) to adipocytes and newly formed blood vessels within the grafts via tunneling nanotubes (TNTs). We demonstrate that Tβ4 upregulates the Rac/F-actin pathway, leading to an increased formation of TNTs and subsequent transfer of mitochondria from ADSCs.
View Article and Find Full Text PDFAesthetic Plast Surg
January 2025
Department of Plastic Surgery and Burns Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515051, Guangdong, China.
Background: Autologous fat injection has been proposed as a potential alternative to traditional rhinoplasty. However, the technique has been criticized for its disappointing retention and the potential complications associated with underfilling.
Objective: To summarize data on patient satisfaction, retention, complications and reinjection to provide a reference for fat injection for rhinoplasty.
J Cosmet Laser Ther
December 2024
Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, P.R. China.
Background: Autologous fat transplantation has gained increasing attention in the field of cosmetic surgery. However, a series of complications can occur after fat transplantation.
Case Presentation: A 24-year-old woman presented at our Hospital with nasal skin necrosis and ulceration.
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