Detection of mast cells in ameloblastomas and odontogenic keratocysts.

J Clin Exp Dent

DDS, MSc, PhD, Full Professor, Department of Surgery and Oral Pathology, Pernambuco Dental School, University of Pernambuco, Camaragibe, Pernambuco, Brazil.

Published: August 2020

AI Article Synopsis

  • MCs (mast cells) are linked to disease progression and may influence conditions like tumors, but their exact role in odontogenic lesions like ameloblastomas (AMBs) and odontogenic keratocysts (OKCs) is unclear.
  • A study analyzed 40 odontogenic lesions (20 OKCs and 20 AMBs) using histological methods and statistical analysis to assess the presence and impact of MCs in these conditions.
  • Results showed that MCs were found more frequently in OKCs (60%) than in AMBs (35%), with significant differences between solid and unicystic AMBs, indicating potential roles for MCs but no definitive conclusions on their biological influence overall.

Article Abstract

Background: MCs (MCs) have been ascribed to mediating several diseases, including malignant neoplasms. These cells can play a role in angiogenesis, tissue remodeling and immune modulation and favor neoplasm progression. Despite the studies analyzing the contribution of MCs in odontogenic lesions, its biological behavior in ameloblastomas (AMBs) and odontogenic keratocysts (OKCs) remains unclear. This study aims to detect MCs in OKCs and AMBs and clarify the role of MCs in these lesions.

Material And Methods: A total of 40 odontogenic lesions were analyzed. This included 20 OKCs and 20 AMBs, 10 being the solid type and the other 10 being the unicystic type of AMB. All cases were histologically reviewed in hematoxylin-eosin. Clinical data, such as age, gender, location, size, radiographic presentation and, histologic patterns were collected from the clinical charts. The Mann-Whitney U test (MWU) was used verify the hypothesis, through inferential statistics. The level of significance used in the statistical test was 0.5%.

Results: MCs were observed in 60% of OKCs, and 35% of AMBs. The ratio of MCs observed in OKCs was 0.37, 0.48 in solid AMBs and 0.01 in unicystic AMBs. There was no significant difference between number of MCs in AMBs and OKCs, however, a significant difference was observed between solid and unicystic AMBs ( ≤ 0.01).

Conclusions: MCs may play an important role in the biological behavior of AMBs and OKCs. However, in this study it was not possible to confirm the contribution of MCs in the biological behavior of these lesions and more studies are needed to clarify this relation. AMB, OKC, MCs, histochemistry, toluidine blue.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474942PMC
http://dx.doi.org/10.4317/jced.56723DOI Listing

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