Background And Aims: The diagnostic yield (DY) and therapeutic yield (TY) of balloon-assisted enteroscopy (BAE) in overt obscure gastrointestinal bleeding (OGIB) is higher in the first 72 h. This study aimed to evaluate if this higher DY and TY after urgent BAE impacted the rebleeding rate, time to rebleed and short-term mortality.
Methods: Retrospective cohort-study, which consecutively included all patients submitted to BAE for overt OGIB, between 2010 and 2019. Patients were distributed in 2 groups: (1) Urgent BAE; (2) Non-urgent BAE. Rebleeding was defined as an Hb drop >2 g/dL, need for transfusional support or presence of melena/hematochezia.
Results: Fifty-four patients were included, of which 17 (31.5%) were submitted to BAE in the first 72 h. DY and TY of urgent BAE (DY 88.2%; = 15; TY 94.1%; = 16) was higher compared to non-urgent BAE (DY 59.5%; = 22; TY 45.9%; = 17) (DY = .03) (TY = .001). The rebleeding rate at 1, 2, and 5 years was 32.0%, 34.0%and 37.0%, respectively. Rebleeding was lower after urgent BAE (17.6%; = 3) compared to non-urgent BAE (45.9%; = 17) ( = .04). Rebleeding tended to occurr earlier in non-urgent BAE, being at 6-months (32.5%) and 36 months (41.3%) ( = .05). OGIB related 30-day mortality was 5.4% ( = 2) for non-urgent BAE and 0% for urgent BAE ( = .5).
Conclusion: Urgent BAE might be associated with higher DY and TY with lower rebleeding and trend toward higher rebleeding-free time.
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http://dx.doi.org/10.1080/00365521.2020.1813800 | DOI Listing |
Transl Clin Pharmacol
December 2024
Department of Clinical Pharmacology and Therapeutics, Dongguk University College of Medicine and Dongguk University Ilsan Hospital, Goyang 10326, Korea.
In recent years, with the experience of the COVID-19 pandemic, countries around the world have realized that improving patient access to new medicines can have a significant impact on public health and economic stability. The aim of this study was to identify new drugs that are urgently needed among those not yet available in South Korea from 2011 to 2020, and to develop strategies to improve access by analyzing the causes of delay. Through a 3-step screening process that included a literature review of new drugs, surveys of domestic clinicians and academics, and consideration of expedited review status by regulatory authorities, 34 out of 244 unreleased new drugs were prioritized for rapid introduction.
View Article and Find Full Text PDFAnal Chim Acta
January 2025
College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea. Electronic address:
Background: The simplicity of synthesis methods has facilitated the illegal manufacture of various fentanyl analogs, leading to numerous fatal overdoses worldwide, particularly in North America. Fentanyl analogs with similar structures are difficult to distinguish due to their fragmentation patterns, making separation using chromatography essential. Additionally, because fentanyl analogs are lethal even in trace amounts, they are easily smuggled, and commonly used fentanyl test strips often fail to detect them due to their low sensitivity.
View Article and Find Full Text PDFJ Sci Food Agric
December 2024
Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Jinan University, Guangzhou, China.
Background: Wheat gluten (WG) is a crucial cereal protein commonly utilized in the food, biological and pharmaceutical industries. However, WG is poorly soluble in water, resulting in poor functional properties, which restrict its application in the food industry. As a result, there is an urgent need for improving the properties of WG.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg Cases
November 2023
Department of General Thoracic Surgery, Fukuoka Wajiro Hospital, 2-2-75 Wajirogaoka, Higashi-ku, Fukuoka, Fukuoka, 811-0213, Japan.
EuroIntervention
November 2024
Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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