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()-Piplartine Isolated from , a Lead Compound against . | LitMetric

AI Article Synopsis

Article Abstract

The current therapies of leishmaniasis, the second most widespread neglected tropical disease, have limited effectiveness and toxic side effects. In this regard, natural products play an important role in overcoming the current need for new leishmanicidal agents. The present study reports a bioassay-guided fractionation of the ethanolic extract of leaves of against four species of spp. promastigote forms, which afforded six known alkamides (-). Their structures were established on the basis of spectroscopic and spectrometric analysis. Compounds and were identified as the most promising ones, displaying higher potency against spp. promastigotes (IC values ranging from 1.6 to 3.8 µM) and amastigotes of (IC values ranging from 8.2 to 9.1 µM) than the reference drug, miltefosine. The efficacy of ()-piplartine () against infection in an in vivo model for cutaneous leishmaniasis was evidenced by a significant reduction of the lesion size footpad and spleen parasite burden, similar to those of glucantime used as the reference drug. This study reinforces the therapeutic potential of ()-piplartine as a promising lead compound against neglected infectious diseases caused by parasites.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554920PMC
http://dx.doi.org/10.3390/foods9091250DOI Listing

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