AI Article Synopsis
- Spinal cord injury (SCI) disrupts autonomic nervous system functions, particularly affecting cardiovascular regulation, especially in individuals with injuries at or above the T6 level.
- These injuries lead to impaired sympathetic responses, causing issues like reduced vasoconstriction and heart rate control, as well as altered plasma catecholamine levels that impact cardiac function.
- The manuscript discusses the prevalence of cardiovascular problems related to SCI, along with their presentation, diagnosis, consequences, and evidence-based management strategies for treatment.
Article Abstract
Spinal cord injury (SCI) disrupts autonomic circuits and impairs synchronistic functioning of the autonomic nervous system, leading to inadequate cardiovascular regulation. Individuals with SCI, particularly at or above the sixth thoracic vertebral level (T6), often have impaired regulation of sympathetic vasoconstriction of the peripheral vasculature and the splanchnic circulation, and diminished control of heart rate and cardiac output. In addition, impaired descending sympathetic control results in changes in circulating levels of plasma catecholamines, which can have a profound effect on cardiovascular function. Although individuals with lesions below T6 often have normal resting blood pressures, there is evidence of increases in resting heart rate and inadequate cardiovascular response to autonomic provocations such as the head-up tilt and cold face tests. This manuscript reviews the prevalence of cardiovascular disorders given the level, duration and severity of SCI, the clinical presentation, diagnostic workup, short- and long-term consequences, and empirical evidence supporting management strategies to treat cardiovascular dysfunction following a SCI.
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| http://dx.doi.org/10.1055/s-0040-1713885 | DOI Listing |
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