AI Article Synopsis
- Bio-inspired adhesive hydrogels are being developed for cell and drug delivery to treat tissue defects but often lack the necessary properties for effective bone regeneration.
- The study created hybrid hydrogel patches by adding inorganic minerals like hydroxyapatite (HAP) to pyrogallol-conjugated hyaluronic acid, leading to improved mechanical strength and osteoconductivity.
- These hybrid patches also successfully released bone morphogenetic protein-2 (BMP-2) over time and promoted human stem cell differentiation and new bone formation, highlighting their potential use in orthopedic treatments.
Article Abstract
Bio-inspired adhesive hydrogels have been applied to cell and drug delivery systems to address various tissue defects and disorders. However, adhesive hydrogels functionalized with phenolic moieties often lack osteoconductive capacity and mechanical properties for bone regeneration. In this study, we utilized the versatile chemical interactions of phenolic moieties to overcome such limitations in bone tissue engineering efforts. Highly osteoconductive hybrid hydrogel patches were fabricated by incorporating inorganic minerals, hydroxyapatite (HAP), or whitlockite (WKT), into pyrogallol-conjugated hyaluronic acid (HA-PG). The hybrid HA-PG patches exhibited improved mechanical strength and reinforced structural/physical properties owing to additional intermolecular complexation between oxidized PG moieties and ions released from inorganic particles. The sustained release of bone morphogenetic protein-2 (BMP-2) from hybrid patches was prolonged by combination of the inherent nucleophilic affinity of oxidized PG and electrostatic interactions between inorganic particles and BMP-2. With increased osteoconductivity, hybrid patches with HAP or WKT enhanced the osteogenic differentiation of human stem cells while also promoting new bone formation in a critical-sized calvarial defect. Our study demonstrates a translational potential of phenolic adhesive hydrogels engineered with inorganic minerals for orthopedic applications.
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| http://dx.doi.org/10.1016/j.jconrel.2020.09.006 | DOI Listing |
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