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To comprehensively understand the chemical constituents of the edible mushroom and their biological functions, a phytochemical separation of the cultural broth of led to the isolation of four new illudane sesquiterpenoids, agrocybins H-K (-), along with 10 known analogues (-). Compounds - were racemates of which and were further separated into single enantiomers as / and /. All new structures with absolute configurations were elucidated on the basis of an extensive spectroscopic analysis and quantum chemistry calculations. Compound possesses a new carbon skeleton that might be derived from the protoilludane backbone. Compounds , , , and show a certain degree of cytotoxicity to five human cancer cell lines. Compound shows a mild inhibitory effect on nitric oxide production with an IC value of 31.4 μM. It is concluded that is rich in illudin derivatives with potential bioactivity prospects, which would make a good material of medicine and food homology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469647 | PMC |
| http://dx.doi.org/10.1021/acsomega.0c03314 | DOI Listing |
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