Coughs are one of the primary means of transmission of diseases such as influenza and SARS-CoV-2 (COVID-19). Disease spreading occurs by the expulsion of pathogen containing aerosol droplets. Fine droplets can pass through layers of masks and are carried away by the exhaled airflow unlike larger droplets that settle down due to gravity. Hence, it is important to quantitatively assess the maximum distance of travel of typical human coughs with and without different types of masks. Even though near field data are available near the mouth, far field data are scarce. In this study, the schlieren method that is a highly sensitive, non-intrusive flow visualization technique is used. It can directly image weak density gradients produced by coughs. An assessment of different methods of covering the mouth while coughing is arrived at by using observations from high speed schlieren images. The effectiveness of coughing into the elbow is examined. The velocity of propagation of coughs and the distance of propagation with and without masks are quantified. It is also found that normalizing the distance-velocity profiles causes all the data to collapse onto a universal non-dimensional curve irrespective of the usage of different types of masks or test subjects. Visualization of cough flow fields and analysis of experimental data reveal that the flow physics is governed by the propagation of viscous vortex rings.
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http://dx.doi.org/10.1063/5.0021666 | DOI Listing |
Campbell Syst Rev
March 2025
Policy Evaluation and Research Unit Manchester Metropolitan University Manchester UK.
Background: Adults experiencing homelessness in high income countries often also face issues of problematic substance use, mental ill health, in addition to housing instability, so it is important to understand what interventions might help address these issues. While there is growing evidence of the effectiveness of psychosocial interventions for the general population, limited evidence exists specifically for those experiencing homelessness.
Objectives: To summarise the existing evidence of whether psychosocial interventions work in reducing problematic substance use, mental ill health, and housing instability for adults experiencing homelessness in high income countries.
Mosquito ecology and behavior and malaria parasite development display marked sensitivity to weather, in particular to temperature and precipitation. Therefore, climate change is expected to profoundly affect malaria epidemiology in its transmission, spatiotemporal distribution and consequent disease burden. However, malaria transmission is also complicated by other factors (e.
View Article and Find Full Text PDFJ Nucl Med
January 2025
Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;
Tumor metabolism is a hallmark of cancer, yet cellular heterogeneity within the tumor microenvironment presents a significant challenge, as bulk analysis masks the diverse metabolic profiles of individual cell populations. This complexity complicates our understanding of [F]FDG uptake by distinct cell types in the tumor microenvironment. This study aims to investigate [F]FDG uptake at the single-cell level in the lung of Kirsten rat sarcoma virus-driven cancer mouse models using the novel technique radio-flow cytometry (radioFlow).
View Article and Find Full Text PDFLancet Healthy Longev
December 2024
University of the West of England, School of Health and Social Wellbeing, Bristol, UK; Research in Emergency Care, Avon Collaborative Hub (REACH), Bristol, UK.
People living with frailty can experience discrimination, but unlike the characteristics of age and disability, frailty is not protected by law. Frailty is a clinical syndrome associated with ageing in which health deficits increase a person's vulnerability to illness, disability, and death. This scoping review, conducted by a team of methodologists, clinicians, lawyers, and patients, aimed to investigate the extent of discrimination against people living with frailty described in health-care literature.
View Article and Find Full Text PDFVirus Evol
November 2024
Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Hypermutated proviruses, which arise in a single Human Immunodeficiency Virus (HIV) replication cycle when host antiviral APOBEC3 proteins introduce extensive guanine to adenine mutations throughout the viral genome, persist in all people living with HIV receiving antiretroviral therapy (ART). However, hypermutated sequences are routinely excluded from phylogenetic trees because their extensive mutations complicate phylogenetic inference, and as a result, we know relatively little about their within-host evolutionary origins and dynamics. Using >1400 longitudinal single-genome-amplified HIV sequences isolated from six women over a median of 18 years of follow-up-including plasma HIV RNA sequences collected over a median of 9 years between seroconversion and ART initiation, and >500 proviruses isolated over a median of 9 years on ART-we evaluated three approaches for masking hypermutation in nucleotide alignments.
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