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| http://dx.doi.org/10.2147/JPR.S265901 | DOI Listing |
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Structure-Activity Relationships of the Fentanyl Scaffold: Identification of Antagonists as Potential Opioid Overdose Reversal Agents.
ACS Chem Neurosci
August 2024
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Opioid-related overdoses account for almost half of all drug overdose deaths in the United States and cause more preventable deaths every year than car crashes. Fentanyl, a highly potent mu opioid receptor (MOR) agonist and its analogues (fentalogues) are increasingly found in illicit drug samples, both where the primary drug of abuse is an opioid and where it is not. The prevalence of fentalogues in the illicit drug market is thought to be the primary driver of the increased number of opioid-related overdose deaths since 2016.
View Article and Find Full Text PDFNew Psychoactive Substances Intoxications and Fatalities during the COVID-19 Epidemic.
Biology (Basel)
February 2023
Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA 19107, USA.
In January 2020, the World Health Organization (WHO) issued a Public Health Emergency of International Concern, declaring the COVID-19 outbreak a pandemic in March 2020. Stringent measures decreased consumption of some drugs, moving the illicit market to alternative substances, such as New Psychoactive Substances (NPS). A systematic literature search was performed, using scientific databases such as PubMed, Scopus, Web of Science and institutional and government websites, to identify reported intoxications and fatalities from NPS during the COVID-19 pandemic.
View Article and Find Full Text PDFMolecular Insights and Clinical Outcomes of Drugs of Abuse Adulteration: New Trends and New Psychoactive Substances.
Int J Mol Sci
November 2022
Department of Excellence of Biomedical Science and Public Health, University "Politecnica delle Marche" of Ancona, Via Tronto 71, 60124 Ancona, Italy.
Adulteration is a well-known practice of drug manufacturers at different stages of drug production. The intentional addition of active ingredients to adulterate the primary drug may enhance or mask pharmacological effects or may produce more potent drugs to increase the number of available doses and the dealer's profit. Adulterants found in different drugs change over time in response to different factors.
View Article and Find Full Text PDFHyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE).
ChemistryOpen
December 2019
Department of Natural Sciences Manchester Metropolitan University John Dalton Building, Chester St. Manchester, M1 5GD UK.
Fentanyl, also known as 'jackpot', is a synthetic opiate that is 50-100 times more potent than morphine. Clandestine laboratories produce analogues of fentanyl, known as fentalogues to circumvent legislation regarding its production. Three pyridyl fentalogues were synthesized and then hyperpolarized by signal amplification by reversible exchange (SABRE) to appraise the forensic potential of the technique.
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