AI Article Synopsis
- Some groups are delaying free-DNA collection for noninvasive preimplantation genetic testing (niPGT-A) to day 6 for all blastocysts, aiming to increase DNA samples.
- A meta-analysis suggested similar live birth rates when transferring euploid blastocysts on days 5 and 6, but this data was based on only two studies.
- A new meta-analysis, including more studies, revealed that adopting day 6 for free-DNA collection could lead to a 1.71 times higher loss of live births.
Article Abstract
Perhaps with the intention of obtaining larger amounts of free-DNA, some groups are routinely postponing and establishing free-DNA collection in culture medium for Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) to day 6 for all blastocysts. A meta-analysis served as the basis for such decision, since statistically similar live birth rates were observed when the transfers of euploid blastocysts were performed on day 5 versus day 6 However, the euploidy analysis was conducted in only two studies However, after including the two more studies we performed a new meta-analysis that clearly showed the risks of losing live births with the decision of adopting the 6th day as the endpoint for gathering free-DNA. We would be losing 1.71x more live births.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558897 | PMC |
| http://dx.doi.org/10.5935/1518-0557.20200075 | DOI Listing |
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