We have developed a combination of light scattering techniques to study and characterize droplets of an ultrasonic spray coater in flight. For this economically relevant spray coater, there is so far no reliable technique to systematically adjust the experimental parameters. We have combined photon correlation spectroscopy and turbidimetry to determine the size and speed of the droplets depending on parameters of the printing process as shroud gas pressure, flow rate, and atomizing power. Our method will allow us to predetermine these parameters to control the properties of the coated films as, e.g., thickness from tens of nanometers to micrometers.
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http://dx.doi.org/10.1364/AO.402579 | DOI Listing |
Int J Mol Sci
July 2024
Department of Botany, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
In recent years, inorganic nanoparticles, including calcium hydroxide nanoparticles [Ca Ca(OH) NPs], have attracted significant interest for their ability to impact plant photosynthesis and boost agricultural productivity. In this study, the effects of 15 and 30 mg L oleylamine-coated calcium hydroxide nanoparticles [Ca(OH)@OAm NPs] on photosystem II (PSII) photochemistry were investigated on tomato plants at their growth irradiance (GI) (580 μmol photons m s) and at high irradiance (HI) (1000 μmol photons m s). Ca(OH)@OAm NPs synthesized via a microwave-assisted method revealed a crystallite size of 25 nm with 34% w/w of oleylamine coater, a hydrodynamic size of 145 nm, and a ζ-potential of 4 mV.
View Article and Find Full Text PDFHeliyon
June 2024
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945, Bucharest, Romania.
Recent advancements in the formulation of solid dosage forms involving active ingredient-cyclodextrin complexes have garnered considerable attention in pharmaceutical research. While previous studies predominantly focused on incorporating these complexes into solid states, issues regarding incomplete inclusion prompted the exploration of novel methods. In this study, we aimed to develop an innovative approach to integrate liquid-state drug-cyclodextrin inclusion complexes into solid dosage forms.
View Article and Find Full Text PDFMaterials (Basel)
February 2024
Faculty of Science and Engineering, Swansea University, Bay Campus, Crymlyn Burrows, Swansea SA1 8EN, UK.
Pharmaceutics
May 2022
Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
In situ calcium pectinate-coated pellets were proposed by applying an alternate coating method to drug-layered pellets to achieve colon-specific drug delivery. Solution layering of metroprolol tartrate, a water-soluble model drug, on inert core pellets was achieved using a centrifugal granulator followed by successive alternate coating with pectin and calcium chloride layers using a fluidized bed bottom spray coater. The effect of the coating sequence on the drug release was studied in phosphate buffer pH 7.
View Article and Find Full Text PDFPharmaceutics
January 2022
Department of Chemical and Biological Engineering, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Oral solid dosage forms that contain APIs in the amorphous state have become commonplace because of many drug substances exhibiting poor water solubility, which negatively impacts their absorption in the human GI tract. While micronization, solvent spray-drying, and hot-melt extrusion can address solubility issues, spray coating of the APIs onto beads and tablets offers another option for producing amorphous drug products. High-level comparisons between bead and tablet coating technologies have the potential for simpler equipment and operation that can reduce the cost of development and manufacturing.
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