Phytochemical, metabolic profiling and antiparasitic potential from leaves (Fabaceae).

Natural Products phytochemical provide a rich source for therapeutic discovery and has led to the development of many drugs. Thus, the aim of this study was to obtaining a metabolic profiling from ethanol extract of leaves (EEIS) selected by bioassay antimalarial and nematostatic and identify metabolites in mixture by co-injection experiments and NMR spectroscopy. The chemical composition of this species indicated a wide variety of aromatic acids (vanillic acid, 3,4,5-trimethoxy benzoic acid, gallic acid, , -coumaric acid and ferulic acid), flavonoids (quercetin, myricetin-3-rhamnoside and myricetin-3--(2"-O-)--rhamnopyranoside), triterpenes (lupeol, -amyrin, friedelin and oleanolic acid) and the 2-hydroxyethyl-dodecanoate. The antimalarial assay showed that the hexane fraction presented higher inhibition percentage than the Chloroquine standard and may be considered a potential source of compounds with antimalarial activity while the and its fractions showed nematostatic potential below 17% in the assay of nematostatic evaluation against the parasite .