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Interfacial Dripping Faucet: Generating Monodisperse Liquid Lenses.
Phys Rev Lett
December 2024
Carlos III University of Madrid, Thermal and Fluids Engineering Department, Avenida de la Universidad, 30 (Sabatini building), 28911 Leganés (Madrid), Spain.
We present a surface analog to a dripping faucet, where a viscous liquid slides down an immiscible meniscus. Periodic pinch-off of the dripping filament is observed, generating a succession of monodisperse floating lenses. We show that this interfacial dripping faucet can be described analogously to its single-phase counterpart, replacing surface tension by the spreading coefficient, and even undergoes a transition to a jetting regime.
View Article and Find Full Text PDFMicrotubule plus-end tracking protein EB1 orchestrates mitotic progression via liquid-liquid phase separation.
J Mol Cell Biol
January 2025
MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Cross-disciplinary Sciences at the Microscale, University of Science & Technology of China School of Life Sciences, Hefei 230027, China.
A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer.
Front Immunol
January 2025
Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.
Background: An increasing body of evidence indicates that dysregulation of liquid-liquid phase separation (LLPS) in cellular processes is implicated in the development of diverse tumors. Nevertheless, the association between LLPS and the prognosis, as well as the tumor immune microenvironment, in individuals with colon cancer remains poorly understood.
Methods: We conducted a comprehensive evaluation of the LLPS cluster in 1010 colon cancer samples from the TCGA and GEO databases, utilizing the expression profiles of LLPS-related prognostic differentially expressed genes (DEGs).
Validated LC-MS/MS Method for the Determination of Paxalisib on Mouse Dried Blood Spots: An Application to Pharmacokinetic Study in Mice.
Biomed Chromatogr
February 2025
Department of Pharmaceutical Analysis, School of Pharmacy, Anurag University, Medchal-Malkajgiri, Hyderabad, Telangana, India.
Paxalisib is a dual PI3K/mTOR inhibitor, being used in advanced cancer treatment. In this research, we report a validated LC-MS/MS method for quantifying paxalisib from mouse dried blood spot (DBS). We validated the method in-line with the FDA guidelines.
View Article and Find Full Text PDFPharmacokinetic Study of Ginkgolide B in Dog After Intravenous Administration.
Biomed Chromatogr
February 2025
Department of Pharmacy, Xuzhou Central Hospital, Xuzhou, China.
Ginkgolide B (GB) is the main active ginkgolide in Ginkgo biloba leaves extract. Pharmacological study suggested that GB exhibits protective effect on nervous system impaired and can be used in the treatment of dementia, cerebral insufficiency or related cognitive decline. However, the information on pharmacokinetics of GB in vivo was limited.
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