The emissions of [Formula: see text] into the environment from the nuclear accidents in Chernobyl in 1986 and Fukushima in 2011 led to the need to decontaminate large areas to avert radiation doses to the population in the affected areas. To be able to perform cost-effective and sustainable remediation, knowledge is needed about how radiation doses can be minimized through optimized interventions such that the greatest possible reduction in radiation dose is obtained with the smallest possible negative impact on the area. Theoretical calculations have been performed to determine how radiation doses in single family houses in a typical Swedish residential suburb arise from a hypothetical [Formula: see text] deposition on the ground. The intention was to highlight how remediation of different parts of the surroundings affects the radiation dose to the residents in a particular property. A Monte Carlo model of the houses and the environment in a suburban area was set up to allow calculations of the dose contributions from different contaminated ground areas such as their own property, neighbouring properties, streets and surrounding recreational areas. Calculations were performed for eleven observation points inside different rooms of the house and one observation point in the garden outside the house, for four houses in the neighbourhood, and for two types of building construction material. The influence of the time spent in different rooms of the house and the contamination of areas surrounding the house was studied. The results show that in general the main dose contribution originates from their own property, but that a significant part (30-80%, depending on the observation point) can come from other areas, showing the importance of considering the surroundings in remediation actions. More detailed analysis of the results showed that the dose contribution from a source region is in general highly dependent on the position of windows in a brick house, whereas for a wooden house the distance to the source region is also of relevance.
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http://dx.doi.org/10.1038/s41598-020-71446-4 | DOI Listing |
BMC Pharmacol Toxicol
January 2025
Biochemistry Department, Faculty of Science, Ain-Shams University, Cairo, Egypt.
Hepatic encephalopathy (HE) is a syndrome that arises from acute or chronic liver failure. This study was devised to assess the impact of a combination of boswellic acid (BA) and low doses of gamma radiation (LDR) on thioacetamide (TAA)-induced HE in an animal model. The effect of daily BA treatment (175 mg/kg body weight, for four weeks) and/or fractionated low-dose γ-radiation (LDR; 0.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.
Background: Agonistic monoclonal antibodies targeting 4-1BB/CD137 have shown preclinical promise, but their clinical development has been limited by severe liver toxicity or limited efficacy. Therefore, a safe and efficient immunostimulatory molecule is urgently needed for cancer immunotherapy.
Methods: A novel anti-MSLN×4-1BB bispecific antibody (bsAb) was generated via antibody engineering, and its affinity and activity were detected via enzyme-linked immunosorbent assay (ELISA), flow cytometry, and T-cell activation and luciferase reporter assays.
Biomed Phys Eng Express
January 2025
Department of Medical Physics, Osaka Heavy Ion Therapy Center, Otemae, Chuo-ku, Osaka, Osaka, 5400008, JAPAN.
Objective Applying carbon ion beams, which have high linear energy transfer and low scatter within the human body, to Spatially Fractionated Radiation Therapy (SFRT) could benefit the treatment of deep-seated or radioresistant tumors. This study aims to simulate the dose distributions of spatially fractionated beams (SFB) to accurately determine the delivered dose and model the cell survival rate following SFB irradiation. Approach Dose distributions of carbon ion beams are calculated using the Triple Gaussian Model.
View Article and Find Full Text PDFHealth Phys
January 2025
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, China.
Inhalation of 131I is the main route for internal doses to nuclear medicine workers. This study aimed to establish a simple analysis method for determining 131I activity in carbon cartridges, explore the activity concentration of 131I in nuclear medicine departments, and evaluate the internal dose of workers. A total of 21 nuclear medicine departments in the hospital conducted air sampling using a high-volume air sampler equipped with carbon cartridges and glass fiber filters to collect gaseous 131I and aerosol 131I, respectively.
View Article and Find Full Text PDFAm J Cancer Res
December 2024
Department of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital Yilan 265, Taiwan.
Betel nut chewing, common in several Asian populations, is linked to increased cancer risk, including oral, esophageal, gastric, and hepatocellular carcinoma. Aspirin shows potential as a chemopreventive agent. This study investigates the association between aspirin use and cancer risk among betel nut chewers.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!