Background: RNA splicing, a fundamental step in gene expression, is aimed at intron removal and ordering of exons to form the protein's reading frame.
Objective: This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities that lead to tumor progression emerge as targets for therapeutic intervention.
Methods: We discuss the role of aberrant mRNA splicing in carcinogenesis and drug response.
Results And Conclusion: Pharmacological modulation of RNA splicing sets the stage for treatment approaches in situations where mRNA splicing is a clinically meaningful mechanism of the disease.
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| http://dx.doi.org/10.2174/1574892815666200908122402 | DOI Listing |
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RNA splicing: a split consensus reveals two major 5' splice site classes.
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