The endocrinological complications are a great concern in transfusion-dependent β-thalassemia (β-thal) patients. The pituitary iron deposition is regarded as the main cause of hormonal changes in thalassemic patients. In this study, our aim was to explore the association between endocrinological complications and pituitary iron overload by magnetic resonance imaging (MRI). Fifty transfusion-dependent thalassemia (TDT) patients were recruited for the study. Pituitary MRIs of patients were taken using a 1.5 Tesla Philips MRI machine. There was at least one clinical endocrine complication in two of three patients. The iron accumulation was moderate in the liver (60.0%) and was mild in hypophysis (16.0%) and in heart (8.0%). The hypogonadism and diabetes mellitus (DM) were not seen with a significantly increased pituitary iron burden. The hypogonadism was related to cardiac iron deposition ( = 0.04). The short stature was associated with a hepatic iron overload ( = 0.05). The conventional follow-up of patients with TDT might be inadequate and screening of patients with MRI of hypophysis along with heart and liver leads to better results.

Download full-text PDF

Source
http://dx.doi.org/10.1080/03630269.2020.1812636DOI Listing

Publication Analysis

Top Keywords

pituitary iron
16
iron deposition
12
patients
8
endocrinological complications
8
iron overload
8
iron
6
pituitary
5
deposition endocrine
4
endocrine complications
4
complications patients
4

Similar Publications

Objective: Heavy menstrual bleeding (HMB) is a significant health concern that may lead to critical medical care and impaired quality of life. The aim of the present study was to identify the clinical indicators of common causes of HMB in adolescents and evaluate the factors influencing the treatment preferences of clinicians.

Methods: Between 2010 and 2022, the electronic medical records of adolescents between the ages of 10-18 with HMB were reviewed, and a final of 205 adolescents was included.

View Article and Find Full Text PDF

Reproductive Health in Women with Major β-Thalassemia: Evaluating Ovarian Reserve and Endocrine Complications.

Metabolites

December 2024

IVF Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.

Article Synopsis
  • Thalassemia is a genetic blood disorder causing anemia due to impaired production of hemoglobin chains, leading to the breakdown of red blood cells.
  • Regular blood transfusions, the standard treatment, can result in iron overload that adversely affects major organs, particularly in women, increasing risks of hormonal issues and reproductive challenges.
  • The review discusses the disease's impact on female reproductive health and the potential of metabolomics to guide better treatment approaches for managing thalassemia-related complications.
View Article and Find Full Text PDF

STRUCTURAL AND FUNCTIONAL BONE FEATURES IN CHILDREN RESIDING IN THE RADIOLOGICALLY CONTAMINATED TERRITORIES OF UKRAINE.

Probl Radiac Med Radiobiol

December 2024

State Institution «National Research Center of Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.

Objective: Evaluation of structural features and metabolic/biochemical abnormalities of the bone tissue and relevant regulation patterns in children, residing in the radiologically contaminated territories (RCT).

Materials And Methods: Children (n = 148) aged 7 to 18 years old were involved in the study. Bone mineral density (BMD) is given in 3 grades according to the mean square deviation values, namely Grade I - standard (n = 75),Grade II - reduced (n = 45) and Grade III - very low one (n = 28).

View Article and Find Full Text PDF

Objective: To determine the structure of abnormalities of bone tissue and substantiate the management tactics inacute lymphoblastic leukemia (ALL) pediatric patients and in children with no oncohematological disorders, livingin radiologically contaminated territories (RCT).

Materials And Methods: Children (n = 220) living in RCT were the study participants i.e.

View Article and Find Full Text PDF

Background: In patients with thalassemia, different organs are affected differently by iron overload. Nevertheless, the reasons for this could be the same key transporters. This study investigated the iron deposition in different organs of transfusion-dependent thalassemia (TDT) patients and its correlation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!