Pan-Echinocandin-Resistant Bloodstream Infection Complicating COVID-19: A Fatal Case Report.

Coinfections with bacteria or fungi may be a frequent complication of COVID-19, but coinfections with species in COVID-19 patients remain rare. We report the 53-day clinical course of a complicated type-2 diabetes patient diagnosed with COVID-19, who developed bloodstream infections initially due to methicillin-resistant , secondly due to multidrug-resistant Gram-negative bacteria, and lastly due to a possibly fatal . The development of -associated pan-echinocandin resistance in the isolated from the patient after 13 days of caspofungin treatment aggravated the situation. The patient died of septic shock shortly before the prospect of receiving potentially effective antifungal therapy. This case emphasizes the importance of early diagnosis and monitoring for antimicrobial drug-resistant coinfections to reduce their unfavorable outcomes in COVID-19 patients.