Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus.

Pathogens

State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046, China.

Published: September 2020

Foot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pathways to achieve immune escape. Strategies to escape the cell immune system are key to effective infection and pathogenesis. This review is focused on summarizing the recent advances to understand how the proteins encoded by FMDV antagonize the host innate and adaptive immune responses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558374PMC
http://dx.doi.org/10.3390/pathogens9090729DOI Listing

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