AI Article Synopsis
- Acute RNA viral encephalomyelitis is a severe complication of various viral infections, and having antibodies in the cerebral spinal fluid (CSF) is linked to improved recovery outcomes.
- The study reviews RNA viruses that lead to acute encephalomyelitis and highlights the role of antibody-secreting cells (ASCs) in combating the infection within the central nervous system (CNS).
- It emphasizes the importance of understanding immune responses in the CNS to create effective treatments for these viral infections, including the unique ways antibodies may operate to protect vital neurons.
Article Abstract
Acute RNA viral encephalomyelitis is a serious complication of numerous virus infections. Antibodies in the cerebral spinal fluid (CSF) are correlated to better outcomes, and there is substantive evidence of antibody secreting cells (ASCs) entering the central nervous system (CNS) and contributing to resolution of infection. Here, we review the RNA viruses known to cause acute viral encephalomyelitis with mechanisms of control that require antibody or ASCs. We compile the cytokines, chemokines, and surface receptors associated with ASC recruitment to the CNS after infection and compare known antibody-mediated mechanisms as well as potential noncytolytic mechanisms for virus control. These non-canonical functions of antibodies may be employed in the CNS to protect precious non-renewable neurons. Understanding the immune-specialized zone of the CNS is essential for the development of effective treatments for acute encephalomyelitis caused by RNA viruses.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551998 | PMC |
| http://dx.doi.org/10.3390/v12090988 | DOI Listing |
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