AI Article Synopsis
- The bone marrow microenvironment (BMM) plays a crucial role in influencing the behavior of multiple myeloma and leukemic cells by producing various molecules and maintaining low oxygen levels, which can affect cell survival and drug resistance.
- Tumor cells receive support from various cell types (e.g., osteoblasts, stromal cells, and endothelial cells) within the BMM, all of which help promote tumor growth and progression.
- The review highlights how the BMM contributes to environmental-mediated drug resistance in blood cancers through mechanisms like cell adhesion and soluble factors, emphasizing the importance of understanding this interaction in developing effective treatments.
Article Abstract
The bone marrow microenvironment (BMM) provides input via production of cytokines, chemokines, extracellular matrixes in the context of lower oxygen levels that influences self-renewal, survival, differentiation, progression, and therapeutic resistance of multiple myeloma and leukemic cells. Within the context of the BMM, tumor cells are supported by osteoblasts, bone marrow stromal cells (BMSCs), fibroblasts, myeloid cells, endothelial cells and blood vessels, as well as extracellular matrix (ECM) that contribute to tumor progression. Environmental mediated-drug resistance (EM-DR) contains cell adhesion-mediated drug resistance (CAM-DR) and soluble factor-mediated drug resistance (SM-DR) that contributes to de novo drug resistance. In this review, we focus on the crosstalk between the BMM and tumor cells as well as mechanisms underlying the BMM contributing to drug resistance in hematologic malignancies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770000 | PMC |
| http://dx.doi.org/10.1016/j.coph.2020.08.006 | DOI Listing |
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