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| http://dx.doi.org/10.1002/ctm2.165 | DOI Listing |
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Progressive systemic inflammation precedes decompensation in compensated cirrhosis.
JHEP Rep
February 2025
Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramon y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá, Madrid, Spain.
Background & Aims: Systemic inflammation is a driver of decompensation in cirrhosis with unclear relevance in the compensated stage. We evaluated inflammation and bacterial translocation markers in compensated cirrhosis and their dynamics in relation to the first decompensation.
Methods: This study is nested within the PREDESCI trial, which investigated non-selective beta-blockers for preventing decompensation in compensated cirrhosis and clinically significant portal hypertension (CSPH: hepatic venous pressure gradient ≥10 mmHg).
Local adaptation and phenotypic plasticity in two forest understorey herbs in response to forest management intensity.
AoB Plants
January 2025
Plant Evolutionary Ecology, Faculty of Biological Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 13, 60438 Frankfurt am Main, Germany.
Local adaptation is a common phenomenon that helps plant populations to adjust to broad-scale environmental heterogeneity. Given the strong effect of forest management on the understorey microenvironment and often long-term effects of forest management actions, it seems likely that understorey herbs may have locally adapted to the practiced management regime and induced environmental variation. We investigated the response of and to forest management using a transplant experiment along a silvicultural management intensity gradient.
View Article and Find Full Text PDFTropical tree species with high wood specific gravity have higher concentrations of wood phosphorus and are more efficient at resorbing it.
AoB Plants
January 2025
CNRS, UMR Ecologie des Forêt de Guyane (EcoFoG), AgroParisTech, CIRAD, INRAE, Université des Antilles, Université de Guyane, 97310 Kourou, France.
Phosphorus (P) and potassium (K) play important roles in plant metabolism and hydraulic balance, respectively, while calcium (Ca) and magnesium (Mg) are important components of cell walls. Although significant amounts of these nutrients are found in wood, relatively little is known on how the wood concentrations of these nutrients are related to other wood traits, or on the factors driving the resorption of these nutrients within stems. We measured wood nutrient (i.
View Article and Find Full Text PDFHMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury.
Front Immunol
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Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Rationale: Acute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.
View Article and Find Full Text PDFZBP1 senses DNA triggering type I interferon signaling pathway and unfolded protein response activation.
Front Immunol
January 2025
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
The innate immune system promptly detects and responds to invading pathogens, with a key role played by the recognition of bacterial-derived DNA through pattern recognition receptors. The Z-DNA binding protein 1 (ZBP1) functions as a DNA sensor inducing type I interferon (IFN) production, innate immune responses and also inflammatory cell death. ZBP1 interacts with cytosolic DNA via its DNA-binding domains, crucial for its activation.
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