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Primary staging with 2[18F]-FDG-PET/CT and -PET/MRI and radiotherapy response evaluation with MRI in uterine cervical cancer: an interim analysis of a prospective clinical trial.
EJNMMI Rep
January 2025
Department of Diagnostics and Intervention, Diagnostic Radiology, Umeå University, Umeå, Sweden.
Background: In uterine cervical cancer (UCC), tumour staging is performed according to the 2018 International Federation of Gynecology and Obstetrics (FIGO) system, where imaging is incorporated, or the more generic Tumour Node Metastasis (TNM) classification. With the technical development in diagnostic imaging, continuous prospective evaluation of the different imaging methods contributing to stage determination is warranted. The aims of this interim study were to (1) evaluate the performance of radiological FIGO (rFIGO) and T staging (rT) with 2-fluorine-18-fluoro-deoxy-glucose (2[18F]-FDG)-positron emission tomography with computed tomography (PET/CT) and with magnetic resonance imaging (PET/MRI), compared to clinical FIGO (cFIGO) and T (cT) staging based on clinical examination and conventional imaging, in treatment-naïve UCC, and to (2) identify possible MRI biomarkers for early treatment response after radiotherapy.
View Article and Find Full Text PDFPredicting treatment response and survival in rectal cancer: insights from 18 FDG-PET/MRI post-neoadjuvant therapy.
Int J Colorectal Dis
January 2025
General Surgery Department, HM Sanchinarro University Hospital, Madrid, Spain.
Introduction: Accurate identification of patients with pathologic complete response (pCR) following neoadjuvant radiochemotherapy (RCT) for locally advanced rectal cancer (LARC) is essential. 18-FDG PET/MRI provides metabolic information that complements the morphological assessment of standard MRI, potentially enhancing the differentiation between fibrotic and tumorous tissues post-treatment. This study aims to evaluate the performance of 18-FDG PET/MRI in assessing treatment response compared to standard MRI.
View Article and Find Full Text PDFClinical validity and reproducibility of a visual rating scale for cingulate island sign in a real-world memory clinic: An FDG-PET/MRI study.
Eur J Neurol
January 2025
Padova Neuroscience Center (PNC), University of Padova, Padova, Italy.
Article Synopsis
- The study investigates the effectiveness of a visual score for identifying cingulate island sign (CIS) in differentiating Lewy body disease (LBD) from Alzheimer's disease (AD) using brain imaging.
- The results indicate that patients with LBD have higher CIS scores compared to those with AD, showing notable differences in brain metabolism patterns.
- Although the CIS scale shows good agreement among specialists, lower sensitivity is observed in mild cases of LBD and atypical presentations of AD, suggesting the need for careful interpretation in mixed diagnoses.
Synergy in Neuroimaging: PET-CT and MRI Fusion for Enhanced Characterization of Brain Pathology.
Cureus
November 2024
Diagnostic Radiology, University of Arkansas for Medical Sciences, Little Rock, USA.
Background: Accurate diagnosis and understanding of brain disorders are crucial for the best treatment. While multimodal neuroimaging is essential, it has its limitations. Conventional computed tomography (CT) and magnetic resonance imaging (MRI) provide detailed anatomical information but lack molecular insights, while 18F-fluorodeoxyglucose-positron emission tomography (FDG PET) offers metabolic data but often has limited spatial resolution.
View Article and Find Full Text PDFTreatment of occult radiculopathy in complex regional pain syndrome by anterior cervical discectomy and fusion following localization by [18F]fluorodeoxyglucose radioligand and PET/MRI: illustrative case.
J Neurosurg Case Lessons
December 2024
Neurosurgery Artificial Intelligence Lab, Stanford University School of Medicine, Stanford, California.
Background: The inability to localize pain generators often results in failed back surgery syndrome (FBSS). Structural imaging can identify multiple and/or noncausative abnormalities. Molecular imaging of glucose transporters offers the opportunity to localize metabolically active sites.
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