AI Article Synopsis
- A new method for synthesizing BINOL-derived cationic phosphonites is introduced.
- These phosphonites serve as ancillary ligands in gold (Au) catalysis, enabling the creation of complex 1-(aryl)benzo[5]carbohelicenes with specific regio- and enantioselectivity.
- The process highlights the significance of these ligands in enhancing the reactivity of Au centers, allowing for optimized reactions that yield high quantities of enantioselective products.
Article Abstract
The synthesis of unprecedented BINOL-derived cationic phosphonites is described. Through the use of these phosphanes as ancillary ligands in Au catalysis, a highly regio- and enantioselective assembly of appropriately designed alkynes into 1-(aryl)benzo[5]carbohelicenes is achieved. The modular synthesis of these ligands and the enhanced reactivity that they impart to Au -centers after coordination have been found to be the key features that allow an optimization of the reaction conditions until the desired benzo[5]helicenes are obtained with high yield and enantioselectivity.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756570 | PMC |
| http://dx.doi.org/10.1002/anie.202010021 | DOI Listing |
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