LBSC showed stability in acidic pH, bile and simulated human gastrointenstinal juices. Under static gut model, when passed through oral, gastric and intestinal phases, LBSC was found to be stable as free viable spores and also with various foods such as milk and baby foods, as well as American and European diets. In human studies, modulation of gut microbiota by LBSC was comprehended by whole genome metagenome analysis of fecal samples obtained from pre- and post-treatment of irritable bowel syndrome (IBS) patients. LBSC treatment showed positive modulation in gut microbiota, especially up regulation of phyla such as and , whereas down regulation of , , and . Simultaneously, it has altered various microbiota associated metabolic pathways to create the normalcy of gut microenvironment.
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| http://dx.doi.org/10.1080/19390211.2020.1814931 | DOI Listing |
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