Pegaharines A-G (-), six novel β-carboline alkaloids representing three types of skeleton, were isolated from the seeds of . Compound is a peculiar β-carboline alkaloid characterized by the unprecedented carbon skeleton of an azepine-indole system. Compounds - represent the first examples of heterodimers constructed from rare tetracyclic β-carboline and classic tricyclic β-carboline alkaloids. Compounds and were characterized by X-ray crystallography. Compound exhibited strong antiviral activity against HSV-2, with an IC value of 2.12 ± 0.14 μM.
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| http://dx.doi.org/10.1021/acs.orglett.0c02650 | DOI Listing |
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