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Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing.
Br J Dermatol
October 2024
Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet; Stockholm, Sweden.
Background: Skin wound healing involves a complex gene expression program that remains largely undiscovered in humans. Circular RNAs (circRNAs) and microRNAs (miRNAs) are key players in this process.
Objectives: To understand the functions and potential interactions of circRNAs and miRNAs in human skin wound healing.
Bone marrow-derived mesenchymal stem cell-derived exosome-loaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage.
World J Diabetes
September 2024
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Article Synopsis
- Diabetic intracerebral hemorrhage (ICH) is a severe complication of diabetes, and this study explores how bone marrow mesenchymal stem cell-derived exosomes (BMSC-exo) affect neuroinflammation in diabetic patients post-ICH.
- The research involves isolating and modifying BMSC-exo with microRNA-129-5p (miR-129-5p) and injecting them into diabetic mice with ICH to analyze their effects on inflammation and nerve function.
- Results indicate that BMSC-exo enhance recovery from neuroinflammation, with miR-129-5p playing a key protective role by reducing inflammation and improving neurological outcomes in cases of concurrent diabetes and ICH.
Depletion of lncRNA MEG3 Ameliorates Imatinib-Induced Injury of Cardiomyocytes via Regulating miR-129-5p/HMGB1 Axis.
Anal Cell Pathol (Amst)
December 2023
Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
Imatinib is a classical targeted drug to treat chronic myeloid leukemia (CML). However, it shows cardiotoxicity, which limits its clinical application. Long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) shows proapoptotic properties in human cells.
View Article and Find Full Text PDFRetraction notice to "Effect of microRNA-129-5p targeting HMGB1-RAGE signaling pathway on revascularization in a collagenase-induced intracerebral hemorrhage rat model" [Biomed. Pharmacother. 93 (2017) 238-244].
Biomed Pharmacother
November 2023
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China. Electronic address:
Myocardial fibrosis and calcification are attenuated by microRNA-129-5p targeting Asporin and Sox9 in cardiac fibroblasts.
JCI Insight
May 2023
Department of Anesthesiology & Perioperative Medicine.
Myocardial fibrosis and calcification associate with adverse outcomes in nonischemic heart failure. Cardiac fibroblasts (CF) transition into myofibroblasts (MF) and osteogenic fibroblasts (OF) to promote myocardial fibrosis and calcification. However, common upstream mechanisms regulating both CF-to-MF transition and CF-to-OF transition remain unknown.
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