A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Coronavirus: a shift in focus away from IFN response and towards other inflammatory targets. | LitMetric

Coronavirus: a shift in focus away from IFN response and towards other inflammatory targets.

J Cell Commun Signal

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa, FL, 33612, USA.

Published: December 2020

AI Article Synopsis

  • Over the last 20 years, two beta-coronaviruses, SARS-CoV-1 and MERS-CoV, infected around 8,000 and 2,500 people globally, while SARS-CoV-2 has already impacted 4.23 million individuals in under a year during the COVID-19 pandemic.
  • Research has compared SARS-CoV-2 to other respiratory viruses to understand COVID-19 better, including viruses like MERS-CoV and Influenza A Virus.
  • Findings show that individuals infected with SARS-CoV-2 exhibit a distinct chemokine profile linked to cytokines and monocyte-associated chemokines, suggesting that the immune response, particularly in those with weakened innate immunity, drives COVID-19

Article Abstract

In the past two decades, two beta-coronaviruses, severe acute respiratory syndrome-related coronavirus (SARS-CoV-1) and the Middle East respiratory syndrome-related coronavirus (MERS-CoV), have infected approximately 8000 and 2500 across the globe, respectively (de Wit et al. 2016; Amanat and Krammer 2020). The current viral pandemic, caused by SARS-CoV-2, has already affected 4.23 M in less than a year. Of greater concern, the disease caused by SARS-CoV-2, COVID-19, still has a rapidly increasing global burden (Wu et al. 2020; Zhu et al. 2020). To better understand the biology of COVID-19, an initial barrage of studies compared SARS-CoV-2 to other respiratory viruses: MERS-CoV, SARS-CoV-1, human parainfluenza virus 3 (HPIV3), respiratory syncytial virus (RSV), and Influenza A Virus (IAV). These studies indicate that SARS-CoV-2 infected individuals have a consistent chemokine signature comprising cytokines and monocyte-associated chemokines (CCL2 and CCL8). Therefore, it appears that monocyte cytokine production, particularly in those with a diminished innate immunity, is a driving feature of COVID-19 infection.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476676PMC
http://dx.doi.org/10.1007/s12079-020-00574-3DOI Listing

Publication Analysis

Top Keywords

respiratory syndrome-related
8
syndrome-related coronavirus
8
caused sars-cov-2
8
coronavirus shift
4
shift focus
4
focus ifn
4
ifn response
4
response inflammatory
4
inflammatory targets
4
targets decades
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!