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Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C-Viremic Donors to Hepatitis C-Negative Recipients: An Open-Label Nonrandomized Study.
Ann Intern Med
January 2021
Johns Hopkins University School of Medicine, Baltimore, Maryland (C.M.D., B.B., S.Y., D.M.B., M.A.C., N.B., F.F.N., M.S., D.L.S., N.M.D.).
Early Experience of Sofosbuvir based Combination Therapy in "Real-Life" Cohort with Chronic Hepatitis-C Infection.
J Clin Diagn Res
March 2017
Research Scholar, Department of Physiology, Government College, Surat, Gujarat, India.
Introduction: There is scarcity of data in literature regarding the treatment response with Sofosbuvir (SOF) based therapy in Indian patients with chronic Hepatitis-C Virus (HCV) infection.
Aim: This study was designed to observe initial treatment response to SOF based therapy in a "real-life" cohort of Indian patients with HCV infection.
Materials And Methods: This is a prospective, observational and single center study.
Article Synopsis
- A study evaluated the effectiveness of 4-week regimens of direct-acting antivirals (DAAs) for treating chronic hepatitis C (HCV) in patients with early liver fibrosis, showing potential for shorter treatments to improve adherence and lower costs.
- Results indicated that 40% of those on a 3-drug regimen and 20% on a 4-drug regimen achieved sustained virologic response (SVR) by week 12, with factors like lower viral load and younger age enhancing success rates.
- Adverse events were mostly mild, but the study's nonrandomized design and small sample size limit the generalizability of findings.
An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four-week-old rats treated with known clastogens.
Environ Mol Mutagen
July 1997
Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana 46140, USA.
The bone marrow (BM) micronucleus (MN) test is a sensitive assay for identifying clastogens. However, some clastogenic compounds and metabolites may never reach the BM. The liver has been suggested as an alternative tissue to BM but adult rat liver has a low mitotic index that increases the difficulty of evaluating hepatocytes (HEP) for MN induction.
View Article and Find Full Text PDFModification of apomorphine-induced behaviour following chronic swim exercise in rats.
Neuroreport
June 1992
Department of Physiology, Banaras Hindu University, Varanasi, India.
Four week swim exercise schedule (45 min day-1, 6 days each week) in rats led to a significant adaptive change in functional responsiveness of dopamine receptors (auto-receptors) in the nigrostriatal and mesolimbic system that was evident from the modification of behavioural responses elicited by a low dose of apomorphine, a direct acting dopamine receptor agonist. Thus, a remarkable increase in yawning response, development of full blown stereotypy, as well as profound attenuation of locomotory and hypothermic response was observed in exercise-trained rats as compared with the non-exercise group (control), following intraperitoneal administration of 0.3 mg kg-1 of apomorphine.
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