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Adaptive HIV pre-exposure prophylaxis adherence interventions for young women in Johannesburg, South Africa: a sequential multiple-assignment randomised trial.
Lancet HIV
December 2024
Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa.
Background: Adherence to daily oral pre-exposure prophylaxis (PrEP) is low among African young women, and layered support strategies are needed to improve PrEP adherence in this population. We aimed to evaluate potentially scalable adherence-support strategies for young women aged 18-25 years who initiated PrEP in Johannesburg, South Africa.
Methods: We conducted a sequential multiple-assignment randomised trial at Ward 21 of the Wits Reproductive Health and HIV Institute clinical research site, affiliated with University of the Witwatersrand, Johannesburg, South Africa.
Increasing event-driven HIV pre-exposure prophylaxis use among gay, bisexual and other men who have sex with men in Australia: results from behavioural surveillance 2019-2023.
J Int AIDS Soc
November 2024
Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Introduction: HIV pre-exposure prophylaxis (PrEP) has been publicly available since 2018 in Australia as a daily regimen. In 2019, clinical guidelines were updated to support guidance on event-driven PrEP (ED-PrEP) use. We assessed trends in the PrEP dosing regimen by comparing daily PrEP use to ED-PrEP among cisgender gay, bisexual and other men who have sex with men (GBMSM).
View Article and Find Full Text PDFHIV incidence in people receiving government-subsidised pre-exposure prophylaxis in Australia: a whole-of-population retrospective cohort study.
Lancet HIV
November 2024
Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Article Synopsis
- The study analyzed the effectiveness of subsidised HIV pre-exposure prophylaxis (PrEP) in Australia from April 2018 to March 2023, focusing on HIV incidence among users over a 5-year period.
- A total of 66,206 people were included in the study, with an overall HIV incidence rate of 1.07 per 1000 person-years, indicating that higher adherence to PrEP substantially reduced the risk of HIV acquisition.
- Key factors influencing HIV acquisition included previous treatment for hepatitis C, younger age (18-29), and attending prescribers in areas with lower prevalence of gay men.
Analyzing HIV Pre-exposure Prophylaxis and Viral Suppression Disparities: Insights From America's HIV Epidemic Analysis Dashboard (AHEAD) National Database.
Cureus
August 2024
Family Medicine, Larkin Community Hospital Palm Springs Campus, Hialeah, USA.
Despite advancements in human immunodeficiency virus (HIV) treatment and prevention, disparities in pre-exposure prophylaxis (PrEP) uptake and viral suppression persist across different demographics. This study analyzes data from America's HIV Epidemic Analysis Dashboard (AHEAD) National Database to identify and understand these disparities based on age, gender, and race/ethnicity. In this study, we utilized the AHEAD National Database, which tracks HIV indicators across various demographics, including age, gender, and race/ethnicity.
View Article and Find Full Text PDFBarriers and Facilitators That Influence HIV Pre-exposure Prophylaxis (PrEP)-Prescribing Behaviors Among Primary Care Providers in the Southern United States.
Cureus
August 2024
Research, Sinclair School of Nursing, University of Missouri, Columbia, USA.
The Southern United States (US) bears the highest burden of HIV prevalence in the country, disproportionately affecting African American communities. Despite the proven efficacy of pre-exposure prophylaxis (PrEP) in reducing HIV transmission, its uptake remains suboptimal in this region. This study aimed to identify factors influencing PrEP-prescribing behaviors among primary care providers (PCPs) in the Southern US through the application of the transtheoretical model of behavior change.
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