What Is Known And Objectives: Thiopurines are cornerstone drugs in the treatment of acute lymphoblastic leukaemia (ALL), but their use can be complicated by the incidence of life-threatening leucopenia.
Case Description: We describe a case of a 6-year-old Chinese boy with B-ALL receiving extremely low dose of 6-mercaptopurine (only 4% of recommended dose) during the ALL maintenance therapy phase.
What Is New And Conclusion: Complex pharmacogenetic tests and TDM should be recommended in children with complicated ALL to highlight the large individual variability in the responses to 6-MP exposure and the associated adverse effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/jcpt.13255 | DOI Listing |
Publication Analysis
Top Keywords
extremely low
8
low dose
8
dose 6-mercaptopurine
8
acute lymphoblastic
8
lymphoblastic leukaemia
8
6-mercaptopurine chinese
4
chinese child
4
child acute
4
leukaemia multiple
4
multiple pharmacogenetic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!