Serum Uric Acid Levels among Patients who Died in Recent Year due to Heart Failure with Reduced Ejection Fraction.

Objective: To examine the relationship of uric acid levels in the last one year with exitus due to heart failure (HF) with clinical and demographic data of patients.

Study Design: Cross-sectional, descriptive study.

Place And Duration Of Study: Bilecik State Hospital, Bilecik, Turkey, from January 2019 to January 2020.

Methodology: The files of 90 people who had exitus due to HF were scanned retrospectively. Demographic data and echocardiography results were recorded. Serum uric acid levels were noted in the 2nd month, 6th month, and 12th month by taking the baseline in the last year before exitus. Mean repeated measurements of uric acid levels that changed over time in patients were compared with ANOVA variance analysis. P <0.05 were accepted as statistically significant.

Results: The mean of the left ventricular ejection fraction (LVEF) of the patients was 35.6±6.6%. Mean serum uric acid levels of the patients for one year before excitus were 5.6±2.2 mg/dL (baseline), 6.1±2.3 mg/dL (2th month), 7.1±2.6 mg/dL (6th month), 8.5±3.0 mg/dL (12th month) respectively. There was a statistically significant difference between the basal uric acid mean with the 6th and 12th month uric acid levels both p <0.001. Age and LVEF were not significantly associated with the uric acid increase over time (p=0.250 and p=0.327, respectively) but were statistically different according to gender (p=0.036).

Conclusion: In heart failure with reduced ejection fraction (HFrEF), the uric acid level increases progressively towards the last periods before exitus. This increase is more pronounced in men. Key Words: Heart failure, Serum uric acid levels, Prognosis, Gender.